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The existing methods for donor blood plasma heat treatment inspection are imperfect as they do not allow obtaining reproducible studies results. The effect of the blood plasma heating rate on the functional activity level of proteins it contains is determined in these results. In this work the accuracy improvement methods of measurement of the blood plasma heating duration by calculating the heating duration of a thermophysical equivalent solution in a simulation vessel were considered. To determine the effect of the assumption of no convective heat transfer on the calculation of the time duration required to reach the solution target average volume temperature, two heating simulation methods of the aqueous sodium chloride solution, accounting for convection and for no convection, were compared. The authors presented results of the two simulation methods and in-situ measurements of the solution temperature during blood plasma heating in eight variants of transfusion preparation conditions with different heating rates. A numerical simulation method accounting for convection of the solution in the vessel has allowed obtaining results similar to in-situ measurements compared to a method accounting for no convection; the variable conditions of solution heating were at a rate ranging from 0.19 to 1.44 °C per second. The study results are applicable for the development of a more sophisticated method for the heat treatment inspection of blood plasma in the devices for its preparation for transfusion.

Key words: numerical simulation of temperature fields, calculation of heating duration, blood plasma
Published in: BIOMEDICAL ELECTRONICS
Bibliography link: Lemondzhava V. N., Selishchev S. V. Comparison of numerical simulation methods of temperature fields in a simulation vessel of a device for heating donor blood plasma. Izv. vuzov. Elektronika = Proc. Univ. Electronics. 2026;31(5):577–586. (In Russ.). DOI: 10.24151/1561-5405-2026-31-5-577-586.EHELJN

Vakhtang N. Lemondzhava
National Research University of Electronic Technology, Moscow, Russia

Sergey V. Selishchev
National Research University of Electronic Technology, Moscow, Russia

1. Гудков А. Г., Лазаренко М. И., Леушин В. Ю., Чечеткин А. В. Технологии трансфузиологии. М.: Сайнс-пресс; 2012. 272 с. EDN: YJSHQF.
Gudkov A. G., Lazarenko M. I., Leushin V. Yu., Chechetkin A. V. Transfusion Medicine Technologies. Moscow: Sayns-press; 2012. 272 p. (In Russ.).

2. McCullagh J., Booth C., Lancut J., Platton S., Richards P. Green L. Every minute counts: A comparison of thawing times and haemostatic quality of plasma thawed at 37 °C and 45 °C using four different methods. Transfusion Medicine. 2024;34(4):304–310. https://doi.org/10.1111/tme.13061

3. Лемонджава В. Н., Чечеткин А. В., Гудков А. Г., Леушин В. Ю., Касьянов А. Д., Киселева Е. А. Термолабильность фактора VIII в донорской свежезамороженной плазме крови. Гематология и трансфузиология. 2021;66(4):593–609. https://doi.org/10.35754/0234-5730-2021-66-4-593-609. EDN: AULJOM.
Lemondzhava V. N., Chechetkin A. V., Gudkov A. G., Leushin V. Yu., Kasianov A. D., Kiseleva E. A. Thermolability of factor VIII in donor fresh frozen blood plasma. Gematologiya i transfuziologiya = Russian Journal of Hematology and Transfusiology. 2021;66(4):593–609. (In Russ.). https://doi.org/10.35754/0234-5730-2021-66-4-593-609

4. Tholpady A., Monson J., Radovancevic R., Klein K., Bracey A. Analysis of prolonged storage on coagulation Factor (F)V, FVII, and FVIII in thawed plasma: Is it time to extend the expiration date beyond 5 days? Transfusion. 2013;53(3):645–650. https://doi.org/10.1111/j.1537-2995.2012.03786.x

5. Dhantole L., Dubey A., Sonker A. A study on factors influencing the hemostatic potential of fresh frozen plasma. Asian J. Transfus. Sci. 2019;13(1):23–29. https://doi.org/10.4103/ajts.AJTS_139_17

6. Жданов А. Е., Доросинский Л. Г., Борисов В. И., Негодяев К. Е., Евдоким Л. Обзор методов температурного картирования процесса дефростации криоконсервированных продуктов крови для разработки радиоэлектронных средств трансфузионно-инфузионной терапии. Научное обозрение. Технические науки. 2021;(3):72–78. https://doi.org/10.17513/srts.1361. EDN: LWIJSB.
Zhdanov A. E., Dorosinskiy L. G., Borisov V. I., Negodyaev K. E., Evdochim L. Development radioelectronic equipment for defrosting of cryopreserved blood and its products: Overview of temperature mapping methods in transfusion and infusion therapy. Nauchnoye obozreniye. Tekhnicheskiye nauki = Scientific Review. Technical Science. 2021;(3):72–78. (In Russ.). https://doi.org/10.17513/srts.1361

7. Lemondzhava V. N., Lemondzhava T. Yu., Gudkov A. G., Shashurin V. D., Leushin V. Yu., Kasyanov A. D. Technological optimization of the process of preparation of fresh frozen blood plasma to transfusion in devices for its thermal processing. AIP Conf. Proc. 2023;2605(1):020013. https://doi.org/10.1063/5.0110400

8. Zhdanov A. E., Dorosinskiy L. G., Borisov V. I., Negodyaev K. E. Overview and comparative analysis of plasma thawing system. In: 2021 Ural Symposium on Biomedical Engineering, Radioelectronics and Information Technology (USBEREIT). Yekaterinburg: IEEE; 2021, pp. 53–55. https://doi.org/10.1109/USBEREIT51232.2021.9455092

9. Жданов А. Е., Доросинский Л. Г., Борисов В. И., Негодяев К. Е., Евдоким Л. Оценка фазового перехода плазмы лед-жидкость с помощью радиоизмерительных приборов. Ural Radio Engineering Journal. 2020;4(4):363–375. https://doi.org/10.15826/urej.2020.4.4.001. EDN: VUOCGT.
Zhdanov A. E., Dorosinskiy L. G., Borisov V. I., Negodyaev K. E., Evdochim L. Estimation of ice-liquid plasma phase transition using electronic test equipment. Ural Radio Engineering Journal. 2020;4(4):363–375. (In Russ.). https://doi.org/10.15826/urej.2020.4.4.001

10. Лемонджава В. Н., Селищев С. В. Оценка повторяемости измерений при определении продолжительности нагрева донорской плазмы крови малых объемов. Изв. вузов. Электроника. 2025;30(4):478–486. https://doi.org/10.24151/1561-5405-2025-30-4-478-486. EDN: DMEDZI.
Lemondzhava V. N., Selishchev S. V. Evaluation of measurement repeatability in determining the heating duration of small volumes of donor blood plasma. Izv. vuzov. Elektronika = Proc. Univ. Electronics. 2025;30(4):478–486. (In Russ.). https://doi.org/10.24151/1561-5405-2025-30-4-478-486

11. Välikangas T. Conjugate heat transfer in OpenFOAM. Proceedings of CFD with OpenSource Software, 2016. Ed. H. Nilsson. 14.02.2017. Available at: https://www.tfd.chalmers.se/~hani/kurser/OS_CFD_2016/TuroValikangas/Report_Turo.pdf (accessed: 03.06.2026).

12. Venkatesh B. V. Tutorial of convective heat transfer in a vertical slot. Proceedings of CFD with Open-Source Software, 2016. Ed. H. Nilsson. 23.01.2017. Available at: https://www.tfd.chalmers.se/~hani/kurser/OS_CFD_2016/VarunVenkatesh/Varun_report.pdf (accessed: 03.06.2026).

Information about the publication

UDK: 681.518.25
Publication type: Scientific article
DOI: 10.24151/1561-5405-2026-31-5-577-586
RISC id: EHELJN

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