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The transfer of an osmotic agent into the blood during the procedure of artificial extrarenal blood purification by peritoneal dialysis leads to a decrease in the rate of excess fluid removal from the body and corresponding disturbances in the water-salt balance. To solve this problem, a system for automatic maintaining and regulation of the glucose concentration in a solution for peritoneal dialysis can be used. In this work, a closed-loop system for automatic maintaining of the glucose concentration in the dialysis solution is proposed, which provides effective long-term ultrafiltration. Automatic feedback control is based on a photometric sensor, a mathematical model of the control object and an actuator – a glucose dispenser. The system was tested on a bench simulating a biological object undergoing peritoneal dialysis. The test results showed that the system allows controlling the concentration of glucose in the dialysis solution and the rate of fluid removal from biological objects. Thus, it has been demonstrated that the system allows the increase in the duration of the extrarenal detoxification procedure, the acceleration of fluid removal during peritoneal dialysis, the reduction of expendable materials consumption, and the improvement of the procedure safety compared to ambulatory peritoneal dialysis.

Key words: closed-loop control system, control algorithm, fluid removal, ultrafiltration, peritoneal dialysis, wearable artificial kidney, personalized medicine
Published in: BIOMEDICAL ELECTRONICS
Bibliography link: Zhilo N. M. Control of fluid removal in an automated peritoneal dialysis system. Proc. Univ. Electronics, 2023, vol. 28, no. 4, pp. 518–528. https://doi.org/10.24151/1561-5405-2023-28-4-518-528. – EDN: BKWJAW.
Financial source: the work has been supported by the Russian Foundation for Basic Research (project no. 20-37-90049\20).

Nikita M. Zhilo
Engineer of the Institute of Biomedical Systems, National Research University of Electronic Technology (Russia, 124498, Moscow, Zelenograd, Shokin sq., 1)

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UDK: 615.47:681.542.32:681.516.3
Publication type: Scientific article
Source lang: Russian
DOI: 10.24151/1561-5405-2023-28-4-518-528
RISC id: BKWJAW

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