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Currently, there is no shared sense of how the duration of donor blood plasma heating affects the change in its properties. The results of independent works aimed at determining this effect have significant discrepancies. In this work, for the ongoing study of donor blood plasma properties an experimental setup is presented allowing the heating of a small volume samples with different intensities at a constant temperature of the heat transfer medium. The repeatability of measurements was evaluated in determining the duration of plasma heating using the experimental setup. In each of the four operating modes of the experimental setup 16 runs of the technological operation were performed under conditions of repeatability according to GOST R ISO 21748–2021. Heating duration was set by tracking the changes in temperature of sodium chloride solution which is close to blood plasma in terms of thermal and physical characteristics. Substance temperature was measured by the contact method using thermocouples placed in a polymer container in the form of a tube filled with solution. Comparison of measurement results in each operating mode of the setup was performed, which has made it possible to determine the effect of changes in heating conditions on its repeatability. Comparison of results of repeatability of substance heating in experimental setup and of plasma samples heating with devices used in industrial transfusiology was also performed. The possibility of providing different heating times for small volume of blood plasma samples at a constant temperature of the heat transfer medium under repeatability conditions has been confirmed.

Key words: blood plasma thermal treatment, measurement repeatability evaluation
Published in: BIOMEDICAL ELECTRONICS
Bibliography link: Lemondzhava V. N., Selishchev S. V. Evaluation of measurement repeatability in determining the heating duration of small volumes of donor blood plasma. Izv.vuzov. Elektronika = Proc. Univ. Electronics. 2025;30(4):478–486. (InRuss.).https://doi.org/10.24151/1561-5405-2025-30-4-478-486.
Financial source: the work has been supported by the Russian Science Foundation (grant no. 23-29-00385), https://rscf.ru/en/project/23-29-00385/

Vakhtang N. Lemondzhava
National Research University of Electronic Technology (Russia, 124498, Moscow, Zelenograd, Shokin sq., 1); “Scientific and Production Organization “BIOMEDTECH” LLC (Russia, 124482, Moscow, Zelenograd, bld. 315)

Sergey V. Selishchev
National Research University of Electronic Technology (Russia, 124498, Moscow, Zelenograd, Shokin sq., 1)

1. Bianchi L., Bontempi M., De Simone S., Franceschet M., Saccomandi P. Temperature dependence of thermal properties of ex vivo porcine heart and lung in hyperthermia and ablative temperature ranges. Ann. Biomed. Eng. 2023;51:1181–1198. https://doi.org/10.1007/s10439-022-03122-9

2. Zhdanov A. E., Dorosinskiy L. G., Borisov V. I., Negodyaev K. E. Overview and comparative analysis of plasma thawing system. In: 2021 Ural Symposium on Biomedical Engineering, Radioelectronics and Information Technology (USBEREIT). Yekaterinburg: IEEE; 2021, pp. 0053–0055. https://doi.org/10.1109/USBEREIT51232.2021.9455092

3. Калинина Е. Н., Вильданова Н. С., Кормщикова Е. С., Коновалова Е. А., Исаева Н. В., Кривокорытова Т. В. и др. Контроль качества компонентов крови: выбор методов лабораторного исследования. Сибирский научный медицинский журнал. 2022;42(1):56–61. https://doi.org/10.18699/SSMJ20220106. EDN: GQZNQO.

Kalinina E. N., Vildanova N. S., Kormshchikova E. S., Konovalova E. A., Isaeva N. V., Krivokorytova T. V. et al. Quality control of blood components: Selection of laboratory testing methods. Sibirskiy nauchnyy meditsinskiy zhurnal = Siberian Scientific Medical Journal. 2022;42(1):56–61. (In Russ.). https://doi.org/10.18699/SSMJ20220106

4. Лемонджава В. Н., Чечеткин А. В., Гудков А. Г., Леушин В. Ю., Касьянов А. Д., Киселева Е. А. Термолабильность фактора VIII в донорской свежезамороженной плазме крови. Гематология и трансфузиология. 2021;66(4):593–609. https://doi.org/10.35754/0234-5730-2021-66-4-593-609.EDN: AULJOM.

Lemondzhava V. N., Chechetkin A. V., Gudkov A. G., Leushin V. Yu., Kasianov A. D., Kiseleva E. A. ThermolabilityoffactorVIIIindonorfreshfrozenbloodplasma. Gematologiya i transfuziologiya = Russian Journal of Hematology and Transfusiology. 2021;66(4):593–609. (In Russ.). https://doi.org/10.35754/0234-5730-2021-66-4-593-609

5. Marquez C. P., Petersen J. R., Okorodudu A. O. Critically low sodium levels due to concentration gradients formed in patient samples after undergoing a freeze-thaw cycle. Clin.Chim.Acta. 2018;484:218–222. https://doi.org/10.1016/j.cca.2018.05.020

6. Lemondzhava V. N., Leushin V. Yu., Khalapsina T. M., Agasieva S. V., Gorlacheva E. N., Chizhikov S. V., Markin A. V. Automated systems for thawing cryopreserved blood components. Biomed.Eng. 2018;51(6):385–388. https://doi.org/10.1007/s10527-018-9755-6

7. Жданов А. Е., Доросинский Л. Г., Борисов В. И., Негодяев К. Е., Евдоким Л. Оценка фазового перехода плазмы лед-жидкость с помощью радиоизмерительных приборов. Ural Radio Engineering Journal. 2020;4(4):363–375. https://doi.org/10.15826/urej.2020.4.4.001. EDN: VUOCGT.

Zhdanov A. E., Dorosinskiy L. G., Borisov V. I., Negodyaev K. E., Evdochim L. Estimation of ice-liquid plasma phase transition using electronic test equipment. Ural Radio Engineering Journal.2020;4(4):363–375. (In Russ.). https://doi.org/10.15826/urej.2020.4.4.001

8. Selleng K., Greinacher A. 10 years of experience with the first thawed plasma bank in Germany. Transfus.Med. Hemother. 2021;48(6):350–357. https://doi.org/10.1159/000519700

9. Крылова Л. В. Разработка эффективных способов замораживания и низкотемпературных аппаратов для получения биологически высокополноценной плазмы крови: дис. ... канд. техн. наук. М., 2006. 145 с.

Krylova L. V. Development of effective methods of freezing and low-temperature equipment for obtaining biologically highly complete blood plasma: Cand. Sci. (Eng.) diss. Moscow, 2006.145 p. (In Russ.).

10. Dhantole L., Dubey A., Sonker A. A study on factors influencing the hemostatic potential of fresh frozen plasma.AsianJ. Transfus.Sci. 2019;13(1):23–29. https://doi.org/10.4103/ajts.AJTS_139_17

11. Лемонджава В. Н. Влияние на скорость технологического процесса размораживания плазмы крови принудительных гидродинамических и механических воздействий на биообъект. Биомедицинскаярадиоэлектроника. 2018;(11):48–55. https://doi.org/10.18127/j15604136-201811-08. EDN: VTWZQG.

Lemondzhava V. N. Effect of forced hydrodynamic and mechanical impacts on speed of technological process of defrosting of blood plasma.Biomeditsinskaya radioelektronika = Biomedicine Radioelectronics. 2018;(11):48–55. (In Russ.). https://doi.org/10.18127/j15604136-201811-08

12. Batty P., Hart D. P., Platton S. Optimization of pre-analytical heat treatment for inhibitor detection in haemophilia A. Int. J. Lab. Hem. 2018;40(5):561–568. https://doi.org/10.1111/ijlh.12862

Information about the publication

UDK: 681.518.25
Publication type: Scientific article
Source lang: Russian
DOI: 10.24151/1561-5405-2025-30-4-478-486
RISC id: DMEDZI

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